Sites of cultural production and display, such as galleries, theaters and studios, offer the architect opportunities to critically engage with the allied arts in dialogues that question, stretch, reinforce or undermine expected disciplinary boundaries. When it was opened 25 years ago, the Wexner Center for the Arts began such a dialogue. As former director, Robert Stearns wrote, the building did not allow the visitor to “fall into the comfort zone of conventional solutions” but became a “catalyst” for many forces in the creative process. Current director Sherri Geldin describes the building in a similar vein as both “generous and generative.” In this studio, we will design a new arts center for Denison University in Granville, Ohio. We will use the Wexner Center as a living laboratory in this effort to understand how the architecture of an arts center can be a “catalyst” for action.